• Previous studies demonstrated SPION labeling in a variety of

  2018-10-22

  

  Previous studies demonstrated SPION-labeling in a variety of human (Niemeyer et al., 2010; Song et al., 2007) and animal (Rice et al., 2007; Zhu et al., 2007) stem cells. We used SPION to track MSC in the QUIN model. SPION were internalized in MSC without affecting cellular viability. These data cor

• However as their origin remains unclear

  2018-10-22

  

  However, as their origin remains unclear, here, we aimed to determine their ancestor(s) in the skeletal muscle. The skeletal muscle is highly vascularized and contains a variety of mononucleated cells, including blood, endothelial, fibroblasts, myofiber satellite, immune, and pericytes. Pericytes ca

• Given the proven ability of

  2018-10-22

  

  Given the proven ability of transcription factors to artificially induce pluripotency in somatic order glp-2 (Takahashi and Yamanaka, 2006), the high expression of these factors in the germline (Kurimoto et al., 2008) raises the question of how PGCs are constrained from becoming pluripotent and the

• To the best of our knowledge only

  2018-10-22

  

  To the best of our knowledge, only three metabolites, L-threonine, butyrate, and vitamin C, have been identified so far that act as epigenetic modulators of ESC self-renewal and/or somatic cell reprogramming (Mali et al., 2010; Shyh-Chang et al., 2013; Wang et al., 2009). Interestingly, L-threonine,

• br Acknowledgments We thank Drs P Chambon and R Losson

  2018-10-22

  

  Acknowledgments We thank Drs. P. Chambon and R. Losson for providing Tif1bfl/fl mice and Dr. Nozaki (MAB institute) for modified histone antibodies. This work was supported in part by Grants-in-Aid for Scientific Research (grants 21390289 and 221S0002) and Scientific Research on Innovative Areas

• Having confirmed that the Nanog iPSCs expressed key markers

  2018-10-22

  

  Having confirmed that the Nanog−/− iPSCs expressed key markers of pluripotency, we sought to determine the extent to which the global expression profile of Nanog−/− iPSCs recapitulated that of ESCs. To this end, we performed RNA sequencing (RNA-seq) of two replicates each of control Nanog+/+ ESC, iP

• Several other signaling pathways that include the TGF

  2018-10-20

  

  Several other signaling pathways that include the TGFβ and phosphoinositide 3-kinase (PI3K) pathways have also been implicated in the regulation of EMT. However, the role of TGFβ in EMT (the differentiation vector) and maintenance of undifferentiated hESCs is somewhat complicated. It is believed tha

• Research into embryogenesis and nervous system development h

  2018-10-20

  

  Research into embryogenesis and nervous system development has been instrumental to the identification of factors required for cell specification. Using information gleaned from these studies, many groups have developed induction protocols to instruct hESCs and iPSCs to become a variety of neural ce

• Studies using freshly isolated cells

  2018-10-20

  

  Studies using freshly isolated molarity by dilution from the stromal vascular fraction (SVF) of sWAT characterized ASCs by their plastic adherence in culture, colony-forming capacity and the expression pattern of distinct cell surface markers (Mitchell et al., 2006). These cells can promote angioge

• Following the safety pilot study a long term

  2018-10-20

  

  Following the safety pilot study, a long term functional study was performed where treatment of the rats with StemBells significantly improved their cardiac function as demonstrated by echocardiography. A functional improvement was found in a significantly better fractional shortening in the StemBel

• A niche is defined as

  2018-10-20

  

  A niche is defined as a microenvironment that maintains stem order Phos-tag Acrylamide through growth factors, cell surface proteins and extracellular matrices (ECMs), and is identified in some organs such as the intestine, brain, skeletal muscle, skin and testis (Chen and Chuong, 2012; Gattazzo et

• Neural stem cell transplantation is currently investigated a

  2018-10-20

  

  Neural stem cell transplantation is currently investigated as a treatment for different CNS injuries and disorders. One key challenge for a successful cell therapy is that an inflammatory environment in the diseased CNS might trigger glial differentiation of transplanted NSCs or NPCs (Aboody et al.,

• Recent studies have proposed the involvement of

  2018-10-20

  

  Recent studies have proposed the involvement of CSCs/progenitor tankyrase in cancer initiation, progression, metastasis and therapy failure (Cariati and Purushotham, 2008; Gonzalez-Sarmiento and Perez-Losada, 2008; Lawson et al., 2009; Liu et al., 2005; Lynch et al., 2006; Ponti et al., 2006). Norm

• In this regard murine ESC derivatives bearing

  2018-10-20

  

  In this regard, murine ESC derivatives bearing EGFP transcriptionally controlled via the promoter of the HCN4 gene were reported to coexpress EGFP, HCN4, and other cardiac markers in spontaneously beating foci (Morikawa et al., 2010). Yet, after the EGFP-positive fraction was subjected to cell sorti

• There are three possible explanations for our findings First

  2018-10-20

  

  There are three possible explanations for our findings. First, it is possible that the reprogramming process resulted in iPSCs that were solely derived from methylated FM fibroblasts and not of the unmethylated cells. This assumes that methylated FM fibroblasts were present in our culture, which acc

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