• A number of anti diabetic drugs are available

  2021-11-18

  

  A number of anti-diabetic drugs are available that inhibit α-glucosidase activity, including acarbose, voglibose and miglitol [6,7]. These inhibitors, however, also exhibit undesirable side effects, such as adverse gastrointestinal symptoms and liver toxicity [8,9]. For diabetics, it would therefore

• br Results br Discussion Our cardiomyocyte specific

  2021-11-18

  

  Results Discussion Our cardiomyocyte-specific GR knockout mice did not show spontaneous cardiac hypertrophy unless pressure overload was given to the heart. This finding is somewhat different from previous work of a cardiomyocyte-specific GR Fluticasone propionate mg mouse model using GR-flox

• In the case of acute inflammation such as ischemic

  2021-11-18

  

  In the case of acute inflammation such as ischemic injury of heart, brain, lung and kidney as wells as in the case infection related injury it is now well established that the leukocytes particularly polymorphonuclear (PMNs) Cryptotanshinone are the first responders. Under normal circumstances thes

• Procainamide HCl br Material and methods br Results br Discu

  2021-11-18

  

  Material and methods Results Discussion Propofol is commonly used in operation rooms or intensive care units (ICUs) for critically ill patients. Various clinical trials have demonstrated that the antioxidant, anti-inflammatory, and free-radical-scavenging properties of propofol can provide

• The more important effect of pitolisant is related to

  2021-11-18

  

  The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced Sulfaphenazole synthesis release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcole

• br STAR Methods br Acknowledgments We thank the TCGA PanCanA

  2021-11-18

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• The translation of the HCV genomic RNA is initiated

  2021-11-18

  

  The translation of the HCV genomic RNA is initiated in a different manner, referred to as internal initiation: the 40S subunit directly forms a binary complex with the HCV genomic RNA via an internal RNA sequence called IRES, which is located in the 5′-UTR (Pestova et al., 1998, Tsukiyama-Kohara et 

• Given the role that activation of GC C has

  2021-11-18

  

  Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co

• Overall ABC transporters are hypothesised to prevent

  2021-11-17

  

  Overall, ABC transporters are hypothesised to prevent the penetration of AEDs and other pharmacological compounds into the brain, being a hurdle for therapeutic delivery in neurological diseases. DRE is thought to be in part related to an increased expression of efflux transporters in the BBB, altho

• br Acknowledgements br Introduction Protein translation dema

  2021-11-17

  

  Acknowledgements Introduction Protein translation demands high fidelity. There are number of molecular checkpoints to fulfill this demand. Among these, insuring that a particular tRNA gets aminoacylated by its conjugate amino acid, which in turn is catalyzed by a particular aminoacyl-tRNA synt

• br Declaration of interest br

  2021-11-17

  

  Declaration of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 31471615), the Introduction of Talent Research Start-up Fund of Anhui Polytechnic University (No. 2017YQQ017) and the Pre-research Project of National Natural Sc

• Zalcitabine The role of the ER EK variant which

  2021-11-17

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of Zalcitabine levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from t

• Till date the first line treatment of T

  2021-11-17

  

  Till date, the first line treatment of T2DM is oral metformin followed by oral sulfonylureas, dipeptidyl peptidase-IV-inhibitors, and TZDs. As the disease progresses, injectable glucagon-like peptide-I analogues or ultimately insulin become necessary to maintain glycaemic control. Despite the establ

• However at variance with the well studied

  2021-11-17

  

  However, at variance with the well-studied R form of FBP1 which is flat, the R state of FBP2 is diametrically different, with a perpendicular orientation of the upper and lower dimers (Barciszewski et al., 2016). The cruciform-like R state of FBP2 is stabilized by a unique hydrophobic motif called ‘

• Introduction Thrombotic disorders including ischemic heart d

  2021-11-17

  

  Introduction Thrombotic disorders including ischemic heart disease, deep venous thrombosis, and ischemic stroke represent one of the most common causes of death in the world [1]. All these conditions relate to states accompanied by a shift of hemostasis balance into a coagulation side because of va

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