• We suggest that the FRET enhancement

  2022-07-06

  

  We suggest that the FRET enhancement observed when the modified mD1 protein containing Acd at position 28 was excited at 260nm (), may differ from the diminution in fluorescence observed following excitation at 280nm due to the excitation of different transitions in Trp (i.e., the L and L transition

• Potential roles for S P

  2022-07-05

  

  Potential roles for S1P in angiogenesis, cancer, and autoimmune diseases such as RA have been reported [73]. In RA synoviocytes, S1P has been shown to enhance expression of prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2) in response to the pro-inflammatory cytokines, TNF-α and interleukin (IL)-

• Sirolimus rapamycin and everolimus both of which are

  2022-07-05

  

  Sirolimus (rapamycin) and everolimus, both of which are mTOR inhibitors, are released by commonly used first- and second-generation DES. Considering the relatively high rates of the target vessel failure with currently available DES [12,14,16,45,46], there is a need for a novel drug strategy that pr

• br Results and discussion Computer

  2022-07-05

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as Fmoc-Ser(tBu)-OH receptor 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is

• br Introduction Glycolysis plays a key role in brain

  2022-07-04

  

  Introduction Glycolysis plays a key role in AGK7 energy metabolism [[1], [2], [3]]. It is initiated mainly by hexokinase I (HKI), the major hexokinase isoform of the brain ([3,4] and references therein). Up to 90% of brain HKI is bound to the mitochondrial outer membrane (MOM) through the voltag

• br Regulation of HO expression under

  2022-07-04

  

  Regulation of HO-1 expression under conditions of ischemic cardiac damage Heart is a vital organ with high metabolic demand, rich in mitochondria and it is very vulnerable to oxidative damage [85]. Disruption in coronary blood flow following MI leads to hypoxia (a reduction in the amount of avail

• br Acknowledgements This work was supported by a grant from

  2022-07-04

  

  Acknowledgements This work was supported by a grant from the BBSRC (BB/D011809/1) to GJL and The Royal Society to SHS (Uf090321). SIM and AH were the recipients of scholarships from HEC Pakistan. Introduction Iron (Fe) is the fourth most abundant element in the earth’s crust. However, Fe is o

• Introduction Glycine Fig has two pivotal functions as neurot

  2022-07-04

  

  Introduction Glycine (Fig. 1; 1) has two pivotal functions as neurotransmitter in the central nervous system (CNS). Firstly, it can act as an inhibitory neurotransmitter at inhibitory glycinergic synapses where it binds to the strychnine-sensitive glycine-A binding site on glycine receptors (GlyR)

• Solamargine AFB Fapy dG has been

  2022-07-04

  

  AFB1-Fapy-dG has been long recognized as a substrate for nucleotide excision repair [24,25]. However, we recently demonstrated that this lesion is removed by Solamargine excision repair. We showed that DNA glycosylase NEIL1, a member of the Fpg/Nei glycosylase family, could excise AFB1-Fapy-dG from

• br Materials and methods br Results br Discussion l

  2022-07-04

  

  Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d

• Despite the potential promise of both

  2022-07-04

  

  Despite the potential promise of both of these peptides, such compounds are still susceptible to efficient renal filtration (Emmanouel et al., 1978, Holst, 1991, Deacon et al., 1996). However, numerous studies have demonstrated that fatty TAK-875 dervatisation of related regulatory peptides results

• br Conflict of interest statement br Acknowledgements br Int

  2022-07-04

  

  Conflict of interest statement Acknowledgements Introduction Galanin is a multi-functional neuropeptide that is widely distributed in the neuroendocrine system and peripheral tissues of various species. This 29-amino-acid peptide (30 in humans) is proteolytically processed from its precurso

• The Hippo pathway has been

  2022-07-02

  

  The Hippo pathway has been well established as a tumor suppressor pathway and is involved in many diverse biologic processes including cell growth, cell death, and organ size control in organisms, ranging from Drosophila to mammals [4]. Central to this pathway is a kinase cascade in which the Ste20-

• The presence of FBP in nuclei seems to accompany

  2022-07-02

  

  The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas

• br Acknowledgements Funding for this study

  2022-07-02

  

  Acknowledgements Funding for this study is gratefully acknowledged from the Department of Employment and Learning (QC) and the Northern Ireland Chest Heart and Stroke Association (2008107). Introduction Preeclampsia is a major human pregnancy-specific disorder that occurs in at least 5–10% of

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